CD74 downregulation in placental macrophages and its influence on trophoblast cells.

ABSTRACT: Preeclampsia is a disease of pregnant women, which is characterized by hypertension, proteinuria and chronic inflammation. There is a growing body of evidence that cause of preeclampsia lies within immunological aspect of pregnancy. This study aimed to analyze the role of CD74 in preeclampsia with a focus on its influence on communication between placental macrophages (Hofbauer cells) and trophoblasts. We have found CD74 to be highly dysregulated in preeclamptic placenta by real-time RT-PCR and Western blot methods. We identified Hofbauer cells to express the highest levels of CD74 in placenta by immunofluorescence and flow cytometry and that CD74 in preeclamptic Hofbauer cells is lower than in controls. We have performed a transcriptome analysis on human blood monocyte-derived macrophages

ORGANISM(S): Homo sapiens

SUBMITTER: Lukasz Przybyl 

PROVIDER: E-MTAB-3309 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress