ChIP-chip by array of human K562, U937 and CD14+ cells to identify histone modifcations in ENCODE regions

ABSTRACT: Chromatin immunoprecipitation microarray (ChIP-chip) study using 3 human cell lines (K562, U937, CD14+); of 19 histone modifications across 1% of the human genome used in the pilot phase of the ENCODE project.
paper abstract: It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons ("exon-intron marking"), linking chromatin structure and function to co- transcriptional splicing in a variety of eukaryotes. Previous ChIP-sequencing studies suggested that these marking patterns reflect the nucleosomal landscape. By analyzing ChIP-chip datasets across the human genome in three cell types, we have found that this marking system is far more complex than previously observed. We show here tha

ORGANISM(S): Homo sapiens

DISEASE(S): chronic myeloid leukemia

SUBMITTER: David Vetrie 

PROVIDER: E-MTAB-334 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress