Transcription profiling by array of human cancer cell lines K562 and U937

ABSTRACT: Transcription profiling of two cancer cell lines: K562 and U937. It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons ("exon-intron marking"), linking chromatin structure and function to co- transcriptional splicing in a variety of eukaryotes. Previous ChIP-sequencing studies suggested that these marking patterns reflect the nucleosomal landscape. By analyzing ChIP-chip datasets across the human genome in three cell types, we have found that this marking system is far more complex than previously observed. We show here that a range of histone modifications and Pol II are preferentially associated with exons. However, there is noticeable cell-type specificity in the degree of exon mar

ORGANISM(S): Homo sapiens

DISEASE(S): chronic myeloid leukemia

SUBMITTER: David Vetrie 

PROVIDER: E-MTAB-335 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress