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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling by array of human breast cancer MCF-7 cells treated with 17-AAG

ABSTRACT: 17-AAG treatment of MCF-7 Microarray

Files containing additional statistical analysis and data for meta-probesets are available on the FTP site for the experiment, in E-MTAB-339.additional.zip

ORGANISM(S): Homo sapiens

SUBMITTER: Sabrina Ronen

PROVIDER: E-MTAB-339 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

HDAC inhibition induces increased choline uptake and elevated phosphocholine levels in MCF7 breast cancer cells.

Ward Christopher S CS Eriksson Pia P Izquierdo-Garcia Jose L JL Brandes Alissa H AH Ronen Sabrina M SM

PloS one 20130423 4

Histone deacetylase (HDAC) inhibitors have emerged as effective antineoplastic agents in the clinic. Studies from our lab and others have reported that magnetic resonance spectroscopy (MRS)-detectable phosphocholine (PC) is elevated following SAHA treatment, providing a potential noninvasive biomarker of response. Typically, elevated PC is associated with cancer while a decrease in PC accompanies response to antineoplastic treatment. The goal of this study was therefore to elucidate the underlyi ...[more]

PMID: 23626839

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