Specialized reaction to bacterial infection precedes antiviral innate immunity during development of teleost fish

ABSTRACT: During early stages of development, juvenile fish must rely on their innate immune system to defend against pathogens. At these early stages, the immune system is immature and is unlikely to express the full repertoire of genes that control defences. Although vulnerable, these larval fish can still fight of infections, indicating there are active defence mechanisms. Using rainbow trout as a model, we have taken a transcriptomics approach to determine the antibacterial (Aeromonas salmonicida) and antiviral (VHSV) responses to infection at four early life history stages, eyed egg, post-hatch, first feeding and three weeks post-first feeding. We performed microarray analysis using an Agilent 4x44K custom designed array, using a common RNA reference hybridization design. We show that all stage

ORGANISM(S): Oncorhynchus mykiss

SUBMITTER: Sam Martin 

PROVIDER: E-MTAB-3401 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress