Model matters: differences in orthotopic rat hepatocellular carcinoma physiology determine therapy response to sorafenib

ABSTRACT: Purpose: Preclinical model systems should faithfully reflect the complexity of the human pathology. In hepatocellular carcinoma (HCC), the tumor vasculature is of particular interest in diagnosis and therapy. By comparing two commonly applied preclinical model systems, diethylnitrosamine induced (DEN) and orthotopically implanted (McA) rat HCC, we aimed to measure tumor biology non-invasively and identify differences between the models.
Experimental design: DEN and McA tumor development was monitored by magnetic resonance imaging (MRI) and positron emission tomography (PET). A slice-based correlation of imaging and histopathology was performed. Array CGH analyses were applied to determine genetic heterogeneity. Therapy response to sorafenib was tested in DEN and McA tumors.
Results:

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kristian Unger 

PROVIDER: E-MTAB-3507 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress