A Genome-Wide Copy Number Variant Study of Suicidal Behavior

ABSTRACT: Suicide and suicide attempts are complex behaviors that result from the interaction of different factors, including genetic variants that increase the predisposition to suicidal behaviors. Copy number variations (CNVs) are deletions or duplications of a segment of DNA usually larger than one kilobase. These structural genetic changes, although quite rare, have been associated with genetic liability to mental disorders, such as autism, schizophrenia, and bipolar disorder. No genome-wide level studies have been published investigating the potential role of CNVs in suicidal behaviors. Based on single-nucleotide polymorphism array data, we followed the Penn-CNV standards to detect CNVs in 1,608 subjects, comprising 475 suicide and suicide attempt cases and 1,133 controls. Although the initial

INSTRUMENT(S): Illumina Omni1-Quad Beadchip

ORGANISM(S): Homo sapiens

SUBMITTER: Gustavo Turecki 

PROVIDER: E-MTAB-3519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress