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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-seq NS5 Zeb1

ABSTRACT: Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) under normal growth conditions. This resulted in the generation of a genome-wide map of Zeb1 binding to chromatin.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Mus musculus

SUBMITTER: Diogo Castro

PROVIDER: E-MTAB-3560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.

Singh Shalini S Howell Danielle D Trivedi Niraj N Kessler Ketty K Ong Taren T Rosmaninho Pedro P Raposo Alexandre Asf AA Robinson Giles G Roussel Martine F MF Castro Diogo S DS Solecki David J DJ

eLife 20160514

In the developing mammalian brain, differentiating neurons mature morphologically via neuronal polarity programs. Despite discovery of polarity pathways acting concurrently with differentiation, it's unclear how neurons traverse complex polarity transitions or how neuronal progenitors delay polarization during development. We report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repres ...[more]

PMID: 27178982

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