Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Variation and genetic control of chromatin architecture in humans (RNAseq)


ABSTRACT: This data set comprises population (46 samples) measurements of RNA expression levels for a subset of the 1000 Genomes Project CEPH samples. This data was generated as part of the following study: - Population Variation and Genetic Control of Modular Chromatin Architecture in Humans. Cell. 2015 Aug 27;162(5):1039-50. doi: 10.1016/j.cell.2015.08.001. Epub 2015 Aug 20. An additional set of 111 samples from the 1000 Genomes Project (GBR and TSI populations) were also assayed using RNA-seq. This data was generated as part of the following study: - Chromatin 3D interactions mediate genetic effects on regulatory networks.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Emmanouil Dermitzakis 

PROVIDER: E-MTAB-3656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase II, and gene expression in lymphoblastoid cell lines from 47 whole-genome sequenced individuals. We observed that distinct cis-regulatory elements exhibit coordinated chromatin variation across individuals in the form of variable chromatin modu  ...[more]

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