Detection of potential neuroprotective changes at the molecular, anatomical and physiological level in identified human pyramidal cells in response to brain edema and increased intracranial pressure.

ABSTRACT: Here we show a workflow combining single cell electrophysiology, anatomy and molecular biology in neurons identified in situ to assess mRNA expression at single molecule precision and corresponding functional changes in response to edema and increased intracranial pressure. This combination of methods applied to human pyramidal neurons reveals quantitative changes of known and potential targets in the therapy of brain edema and traumatic brain injury.

ORGANISM(S): Homo sapiens

SUBMITTER: Ágnes Zvara 

PROVIDER: E-MTAB-3678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress