Effect of morphine treatment on microbiome in the context of microbial transplant.

ABSTRACT: Morphine causes microbial dysbiosis. In this study we focused on restoration of native microbiota in morphine treated mice and looked at the extent of restoration and immunological consequences of this restoration. Fecal transplant has been successfully used clinically, especially for treating C. difficile infection2528. With our expanding knowledge of the central role of microbiome in maintenance of host immune homeostasis17, fecal transplant is gaining importance as a therapy for indications resulting from microbial dysbiosis. There is a major difference between fecal transplant being used for the treatment of C. difficile infection and the conditions described in our studies. The former strategy is based on the argument that microbial dysbiosis caused by disproportionate overgrowth of a

INSTRUMENT(S): Illumina MiSeq, Applied Biosystems, experimental, Mo-Bio Powersoil extraction kit

ORGANISM(S): Mus musculus domesticus

SUBMITTER: Santanu Banerjee 

PROVIDER: E-MTAB-3723 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress