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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of Mycoplasma pneumoniae II

ABSTRACT: To reconstruct the gene regulatory network of Mycoplasma pneumoniae, cells were treated with different drugs/perturbations or were challenged by gain or loss of function of candidate regulators, or a combination of both.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mycoplasma pneumoniae M129

SUBMITTER: Eva Yus

PROVIDER: E-MTAB-3773 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium.

Junier Ivan I Unal E Besray EB Yus Eva E Lloréns-Rico Verónica V Serrano Luis L

Cell systems 20160526 6

Coordination of transcription in bacteria occurs at supra-operonic scales, but the extent, specificity, and mechanisms of such regulation are poorly understood. Here, we tackle this problem by profiling the transcriptome of the model organism Mycoplasma pneumoniae across 115 growth conditions. We identify three qualitatively different levels of co-expression corresponding to distinct relative orientations and intergenic properties of adjacent genes. We reveal that the degree of co-expression bet ...[more]

PMID: 27237741

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