Transcription profiling by array of peripheral blood mononuclear cells from male and female patients with relapsing remitting multiple sclerosis and healthy controls

ABSTRACT: We measured global mRNA expression in peripheral blood mononuclear cells (PBMC) from 45 individuals, comprising of 23 RRMS patients and 22 healthy controls. A gender-based case-control analysis was performed to derive the differentially expressed genes (DEG) in women and men. In contrast to the distinct blood gene signatures, several biological processes(gene ontology) related to transcriptional regulation was shared among the two gender-based DEG. Further, the systems biology analysis revealed that the several interactors were common to the female and male DEG, predominantly ones that participating in epigenetic regulation of gene expression.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Ramesh Menon 

PROVIDER: E-MTAB-380 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress