Transcriptomic profiles of the acetogen Clostridium ljungdahlii during lithoautotrophic growth with syngas or with H2 and CO2 compared to organoheterotrophic growth with fructose

ABSTRACT: Clostridium ljungdahlii derives energy by acetogenesis as a lithotrophic pathway and as part of various organotrophic pathways. Its recently sequenced genome has made it possible to discover changes in gene expression that occur in different growth modes, from which strategies for biofuel production may be developed. C. ljungdahlii was grown with fructose as an organoheterotrophic substrate and also lithoautotrophically, either on syngas or with H2 as the electron donor and CO2 as the electron acceptor. RNA extracted from all three conditions was analyzed by hybridization to a microarray, and gene expression was compared quantitatively by RNA-Seq of C. ljungdahlii grown with fructose and with H2 and CO2. Results. Strongly upregulated (> 10-fold, p < 0.05) genes with both syngas and H2/CO2

ORGANISM(S): Clostridium ljungdahlii

SUBMITTER: Pravin Shrestha 

PROVIDER: E-MTAB-3806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress