Gastrin, PAI-1 and mucosal growth. Whole organism studies in transgenic mice.

ABSTRACT: We are studying the role of PAI-1 in hypergastrinemic transgenic mice (PAI-1 knockout, HK-ATPase beta knockout and corresponding control strains). As a model of hypergastrinaemia, HK-ATPase beta knockout mice are preferred instead of giving a high dose of proton pump inhibitors daily. We have successfully crossed these two strains and generated double knockout mice (PAI-1--/HK-ATPase--) and 3 different control groups (PAI-1++/HK-ATPase++, PAI-1--/HK-ATPase++ and PAI-1++/HK-ATPase--) (9 animals in each group). The gastric phenotype of all mice has been examined by morphologic and molecular analysis after 12 months. Gastric biopsies and blood samples have been taken for histology, large scale gene expression analysis, verification of mRNA and protein expression and gastrin measurements. Glob

ORGANISM(S): Mus musculus

SUBMITTER: Kristin Norsett 

PROVIDER: E-MTAB-3853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress