Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Tma108, a putative M1 aminopeptidase, is involved in ribosome specialization in Saccharomyces cerevisiae

ABSTRACT: We performed subcellular fractionation of the polysomes associated with the mitochondrial surface (mitopolysomes) in wild type or Tma108 deleted yeast strains and measured the mRNA enrichment in these fractions by competitive hybridization on microarrays against the corresponding total RNAs. This was used to measure the mitopolysomes enrichment of all yeast mRNAs and to compare these enrichments between wild type and tma108 mutant.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Frederic Devaux 

PROVIDER: E-MTAB-3922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The discovery of novel specific ribosome-associated factors challenges the assumption that translation relies on standardized molecular machinery. In this work, we demonstrate that Tma108, an uncharacterized translation machinery-associated factor in yeast, defines a subpopulation of cellular ribosomes specifically involved in the translation of less than 200 mRNAs encoding proteins with ATP or Zinc binding domains. Using ribonucleoparticle dissociation experiments we established that Tma108 dir  ...[more]

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