Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data

ABSTRACT: Mitochondrial heteroplasmy, the presence of more than one mtDNA variant in a cell or individual is not as uncommon as previously thought. It is mostly due to the high mutation rate of the mtDNA and limited repair mechanisms present in the mitochondrion. The phenomenon has been studied mostly in human samples and in medical contexts. Heteroplasmy has also been researched in other species in fields such as forensics or genetic foot printing, but these studies usually focused on contained families within closely related species. Here we describe a large cross-species evaluation of heteroplasmy in mammals. We employed a novel approach to detect mitochondrial heteroplasmy in both novel and previously reported ChIP-sequencing datasets, which include concomitant mitochondrial DNA sequenced in the

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Heterocephalus glaber

SUBMITTER: Diego Villar 

PROVIDER: E-MTAB-3933 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress