Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

ABSTRACT: The neural stem cell (NSC) niche controls the expansion and differentiation of NSCs. Blood vessels are part of this neurogenic niche, but their functional significance for the regulation of NSC differentiation and the mechanisms involved remain unclear. Here, we report that blood vessel formation in the developing mouse and ferret cortex coincided with induction of NSC differentiation in time and space. Moreover, selective inhibition of brain angiogenesis in vessel-specific Gpr124 null embryos caused hypoxia and increased NSC expansion at the expense of differentiation. The hypoxia-inducible factor (HIF)-1Îą mediated this process, as the level of HIF-1Îą controlled NSC differentiation. Niche blood vessels regulated NSC differentiation at least in part by providing oxygen, as exposure to in

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus musculus

SUBMITTER: Bram Boeckx 

PROVIDER: E-MTAB-3941 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress