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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Statins-induced changes in gene expression of pancreatic cancer cells with focus on anti-proliferative effects of statins.

ABSTRACT: Statins, potent lipid-lowering drugs, were also shown to exert anti-proliferative activity. The aim of this study was to identify the biological pathways affected by changes in gene expression activity after statins treatment and to compare the results with observed anti-proliferative effects. The study was performed in vitro on a pancreatic cancer cell line MIA PaCa-2. The changes in gene expression were measured after 24 h of treatment by the statins (atorvastatin, lovastatin, simvastatin, fluvastatin, cerivastatin, pravastatin, rosuvastatin, and pitavastatin). The statins affected expression of a significant number of genes with mevalonate pathway, cell cycle regulation, and DNA replication being the most affected metabolic/signalling pathways.

ORGANISM(S): Homo sapiens

SUBMITTER: Tomas Ruml

PROVIDER: E-MTAB-3979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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