MRNA microarray analysis of the substantia nigra in a mouse model of multiple system atrophy

ABSTRACT: Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by prominent α-synuclein accumulation in oligodendrocytes. In this study we investigated mRNA expression in substantia nigra of MSA transgenic mice (Tg(Plp1-SNCA)1Haa) and wild type controls. This forms part of a larger study in which we investigated miRNA-mRNA regulatory network in substantia nagra and striatum of MSA transgenic mice in pre-motor stage of neurodegenration.

INSTRUMENT(S): fluidic station 450 and Affymetrix scanner 3000

ORGANISM(S): Mus musculus

SUBMITTER: Rimpi Khurana 

PROVIDER: E-MTAB-3985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress