*Gastrulation* Single-cell RNA sequencing of mouse embryos with Tal1 (Scl) knockout - Bertie Göttgens (Gastrulation_RNA_Seq-sc-3711)

ABSTRACT: Tracing early mammalian lineage decisions by single cell genomics. Lewis Wolpert famously called gastrulation the most important time in your life. During this fascinating process, a pluripotent stem cell population in the early embryo gives rise to the three germ layers from which all organ systems develop. Cell signalling and transcriptional networks are known to regulate aspects of gastrulation, but the precise mechanisms have not been investigated at the single cell level. Thus, new principles remain to be discovered that govern the exit from naïve pluripotency, epigenetic priming, stochasticity in transcriptional programmes, symmetry breaking, and acquisition of heritable transcriptome patterns. We have brought together a consortium of experts in single cell genomics, mammalian postim

ORGANISM(S): Mus musculus

SUBMITTER: Vicki Moignard 

PROVIDER: E-MTAB-4026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress