Identification of a novel human memory T cell population with the characteristics of stem-like stress resistance

ABSTRACT: High-dose chemotherapy may kill not only tumor cells but also immunocytes, and frequently induces severe lymphocytopenia. On the other hand, patients who recover from the nadir maintain immunity against infection, suggesting the existence of an unknown memory T cell population with stress-resistance, long-living capacity, proliferation and differentiation. Recently, the differentiation system of T cell memory has been clarified using mouse models. However, the human T cell memory system has great diversity induced by natural antigens derived from many pathogens and tumor cells throughout life, and profoundly differs from the mouse memory system constructed using artificial antigens and transgenic T cells. Here we report a novel human T cell memory population, “young memory” T (TYM) cel

ORGANISM(S): Homo sapiens

SUBMITTER: Kenji Murata 

PROVIDER: E-MTAB-4080 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress