Gene expression profiling in human ADPKD cell lines

ABSTRACT: Changes in gene expression levels were identified by microarray. Samples were human kidney epithelial cell lines derived from patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and unaffected controls. Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most common inherited kidney disease, is due to mutations in PKD1 (85%) or PKD2 (15%) but has a highly variable phenotypic disease expression. We conducted parallel microarray profiling in normal and diseased human PKD1 cystic kidney cells to identify altered signatures of microRNA and mRNA target genes potentially implicated in disease expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Streets 

PROVIDER: E-MTAB-4188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress