Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signalling in lung cancer cells

ABSTRACT: Hyperactivation of the PI3K/AKT pathway is observed in most NSCLCs, promoting proliferation, migration and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mutations of the catalytic subunit of the positive regulator phosphatydil-inositol-3’ phosphate kinase (PIK3CA) and/or mutations of AKT1 itself. However, whereas the effects of AKT activation on mRNAs and proteins in the cell are fairly clear, the role of miRNAs as downstream targets of activated PI3K/AKT signalling is still poorly defined so far. To identify miRNAs that are targets of constitutive signalling of PI3K/AKT in lung cancer cells, we performed miRNA profiling of human lung epithelial cells expressing active mutant AKT1 (E17K), active mutant

ORGANISM(S): Homo sapiens

SUBMITTER: Carmelo Laudanna 

PROVIDER: E-MTAB-4263 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress