Mouse-Monkey Time-series

ABSTRACT: Viral and bacterial infections of the lower respiratory tract are major causes of mortality and morbidity worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. In the study we examined the response of alveolar macrophages from mice and cynomolgus macaques to two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were isolated by bronchoalveolar lavage, exposed to pathogen. Cells and supernatants were collected at defined time points to determine changes in gene expression profile and cytokine production respectively. Our analyses identified a core set of genes that were differentially expressed in both species and across all pa

ORGANISM(S): Macaca_fascicularis

SUBMITTER: Alexander Connor 

PROVIDER: E-MTAB-427 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress