Microarray analysis for the Mode-of-Action study of resveratrol in fission yeast

ABSTRACT: An increasing number of studies have shown that the promising compound resveratrol treats multiple diseases, such as cancer and aging; however, the resveratrol mode-of-action (MoA) remains largely unknown. Here, by virtue of multiple omics approaches, we adopted fission yeast as a model system with the goal of dissecting the common MoA of the anti-proliferative activity of resveratrol. Fission yeast was chosen as the model because of the following reasons: fission yeast is a terrific model to investigate the cell cycle and cell shape; the yeast belongs to the “Crabtree Positive” yeast kingdom, which possesses features similar to the “Warburg Effect” of cancer cells such that the fission yeast prefers to conduct fermentation with glucose as the carbon source for energy production ;

ORGANISM(S): Schizosaccharomyces pombe 972h-

SUBMITTER: Zhe Wang 

PROVIDER: E-MTAB-4399 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress