Testis-to-ovary reprogramming and testis regression after ablation of Sox9 in Sox8-/- mice

ABSTRACT: We used two Sertoli-cell-specific Cre lines: Wt1-CreERT2 and Sox9-CreERT2, to induce Sox9 ablation on a Sox8 -/- background in the adult testis. Sox9/8 double KO testes undergo testis-to-ovary genetic reprogramming and Sertoli-to-granulosa cell transdifferentiation.

INSTRUMENT(S): HPC services from the University of Granada (http://alhambra.ugr.es), Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Miguel Burgos 

PROVIDER: E-MTAB-4572 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress