Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk

ABSTRACT: Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein interaction domains, thus playing a critical role in signal transduction from receptor tyrosine kinases to form protein networks. Physiological studies of SH2B function in mammals have produced conflicting data. However, a recent study in Drosophila has shown that Lnk is an important regulator of the insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway during growth, functioning in parallel to the insulin receptor substrate, Chico. As this pathway also has an evolutionary conserved role in the determination of organism lifespan, we investigated whe

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Dobril Ivanov 

PROVIDER: E-MTAB-4612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress