Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GvHD

ABSTRACT: Graft-versus-Host Disease (GvH) is the excessive inflammatory response by mature T cells contained in the graft during bone marrow transplantation. The allogeneic T cells recognize self-antigens as foreign and systemically attack multiple organs mostly with epithelial structures such as the skin, liver and gastrointestinal tract. We could show that IL-33 administration during allogeneic hematopoietic cell transplantation (alloHCT) increased regulatory T cell (Treg) numbers and ameliorated the outcome of GvHD. Furthermore, it is known that IL-33 also has an impact on myeloid cell compartments and we showed that IL-33 delivery together with a loss of FoxP3 positive Treg led to a massive expansion of myeloid cells. With the underlying experiment we wanted to further characterize the myeloid c

ORGANISM(S): Mus musculus

SUBMITTER: Dietmar Pfeifer 

PROVIDER: E-MTAB-4677 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress