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Identifications of genes involved in Friedreich Ataxia pathophysiology

ABSTRACT: We identified a synthetic siRNA (B11) that improves the growth of primary human fibroblasts derived from Friedreich ataxia (FA) patient. A control siRNA, in which one base pair of B11 is mutated (Mut1), was associated with a partial loss of phenotype. This experiment compares the transcriptome of primary FA fibroblasts transfected with B11 siRNA versus the transcriptome of FA cells transfected with Mut1.

INSTRUMENT(S): GeneChip 3000 7G scanner

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Wilson

PROVIDER: E-MTAB-4699 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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