IN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN ORAL TISSUE CULTURES

ABSTRACT: Besides its well-known effects increasing predisposition to oral cancer, cigarette smoke (CS) exposure is an important risk factor for many conditions including periodontal diseases, gingivitis and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing risk of smoking-related diseases. However, reduction of harmful constituents by heating rather than combusting tobacco, without modifying the amount of nicotine, is a promising new paradigm in harm reduction. In this study we compared effects of exposure to aerosol derived from a candidate modified risk tobacco product, the tobacco heating system (THS) 2.2, with those of conventional smoke generated from the 3R4F reference cigarette. Human organotypic oral epithelial tissue cultures (EpiOralﾙ,

ORGANISM(S): Homo sapiens

SUBMITTER: Vincenzo Belcastro 

PROVIDER: E-MTAB-4742 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress