Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma

ABSTRACT: Osteosarcoma (OS) is the most common primary malignant tumor of bone; it occurs most commonly in the metaphyseal regions of long bones in adolescents and young adults. Conventional osteosarcoma is characterized by complex karyotypes with a high degree of aneuploidy and numerous structural aberrations such as copy number alterations (CNAs) and genomic rearrangements. We characterized the landscape of somatic copy number alterations (SCNAs) in a large cohort (n=160) of osteosarcoma (OS) samples using the whole-genome CytoScan High Density arrays. This experiment is an extension of E-MTAB-3998. It contains data for 97 samples that is also included in E-MTAB-3998. The samples derived from E-MTAB-3998 identified using the 'Description' field in the sample attributes.

ORGANISM(S): Homo sapiens

SUBMITTER: Hongen Xu 

PROVIDER: E-MTAB-4815 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress