Genes affected by manipulation of LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer

ABSTRACT: The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked down (by siRNA) or overexpressed in MCF10A cells and RNA level of genes was measured using Affymetrix gene expression arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Aldema Sas-Chen 

PROVIDER: E-MTAB-4821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress