The angiogenic switch leads to a metabolic shift in human glioblastoma

ABSTRACT: The gene expression profiles of two groups of triplicate human glioblastoma (GBM) xenografts grown in immunodeficient rats were compared. The first group of xenografts was derived from a patient biopsy with Epidermal Growth Factor Receptor (EGFR) amplification which grows highly invasive and is independent of angiogenesis. The second group was obtained by introducing a dominant-negative EGFR mutant into the tumor cells, leading to a progression of the tumors to an angiogenic phenotype associated with a transition from a proneural to a mesenchymal GBM molecular subtype.

INSTRUMENT(S): Affymetrix GeneChip Scanner 3000

ORGANISM(S): Homo sapiens

SUBMITTER: Hrvoje Miletic 

PROVIDER: E-MTAB-4898 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress