Effect of estradiol and tamoxifen on SPEN-expressing and control T47D cells.

ABSTRACT: Split Ends (SPEN) is a transcriptional coregulator that have formerly identified as a tumour suppressor gene in ER-positive breast cancers. However, ER-positive breast cancers are diagnosed at similar frequencies in pre- and post-menopausal women who show significantly different circulating hormone levels. This therefore raises the possibility that SPEN functions under hormone-depleted settings may contrast with its roles in the presence of hormones. We therefore attempted to explore the cellular functions regulated by SPEN under hormone-depleted settings using a previously established model with T47D cells stably transfected with a control vector (non-target) or SPEN-expressing vector. In particular, we attempted to investigate the hormone-independent transcriptional program regulated by

ORGANISM(S): Homo sapiens

SUBMITTER: Stéphanie Légaré 

PROVIDER: E-MTAB-4975 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress