DNA methylation in schizophrenia in different patient-derived cell types

ABSTRACT: DNA methylation of gene promoter regions represses transcription and is a mechanism via which environmental risk factors could affect cells during development in individuals at risk for schizophrenia. We investigated DNA methylation in patient-derived cells that might shed light on early development in schizophrenia. Induced pluripotent stem cells (iPS cells) may reflect a “ground state” upon which developmental and environmental influences would be minimal. Olfactory neurosphere-derived cells (ONS cells) are an adult-derived neuro-ectodermal stem cell modified by developmental and environmental influences. Fibroblasts provide a non-neural control for life-long developmental and environmental influences. Genome-wide profiling of DNA methylation and gene expression was done in these thr

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Matigian 

PROVIDER: E-MTAB-5016 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress