Transcription profiling by array of human liver to investigate pathways of Oxaliplatin Related Sinusoidal Obstruction

ABSTRACT: Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxaliplatin. It is associated with substantial morbidity and mortality. Pathogenesis of SOS in humans is poorly understood. To explore its molecular mechanisms, we used Affymetrix U133 Plus 2.0 microarrays to investigate the gene expression profile of 11 human livers with oxaliplatin-related SOS and compared it to 12 matched controls. Hierarchical clustering analysis showed that profiles from SOS and controls formed distinct clusters. To identify functional networks and gene ontologies, data were analyzed by the Ingenuity Pathway Analysis Tool. A total of 913

ORGANISM(S): Homo sapiens

SUBMITTER: Celine Delucinge Vivier 

PROVIDER: E-MTAB-503 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress