Transcription profiling of immature and LPS-matured dendritic cells, sorted for DC-S and DC-L phenotypes

ABSTRACT: We have described two human, monocyte-derived dendritic cells (DC), which we have termed DC-S (small) and DC-L (large). Human dendritic cells are significantly less well known that murine ones, yet they are a crucial player in the immune system, especially when considering options for immunotherapies. Specifically, monocyte-derived dendritic cells, which are the most amenable for clinically relevant work, are considered by many as only reactive, inflammatory cells. In my work I showed that in fact they consist of two subpopulations, with diverging characteristics: one is steady state-like and more tolerizing in its phenotype (DC-S), and the other is more “dangerous”, with an inflammatory phenotype (DC-L). This has important implications for the immunobiology of dendritic cells and also

ORGANISM(S): Homo sapiens

SUBMITTER: Uriel Trahtemberg 

PROVIDER: E-MTAB-5075 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress