The male determining M-factor of the global disease vector Musca domestica is a paralog of the generic splice factor CWC22

ABSTRACT: Sex determination mechanisms are bewilderingly diverse. A cascade of genes with hierarchical regulation characterizes sex determination pathways in insects. How such pathways evolve is poorly understood, partly due to a lack of comparative data. Houseflies are well known for their polymorphic sex determination with populations carrying a dominant male determiner M on the Y chromosome or any of the five autosomes. We identified the male determining gene Mdm responsible for splicing regulation of the key switch transformer by exploiting the existence of housefly populations with different sex determination mechanisms. We demonstrate that Mdm originated from duplication of CWC22/nucampholin, a generic and essential splicing regulator across Metazoans with a crucial role in exon-junction comp

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Musca domestica

SUBMITTER: Mark Robinson 

PROVIDER: E-MTAB-5080 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress