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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Methylome profiling of glioblastoma biopsies obtained by neuro-navigation in four distinct areas for 10 patients (necrotic zone, tumor zone, interface, and peripheral brain zone).

ABSTRACT: We classified samples and deciphered a key genes signature of intratumor heterogeneity by Principal Component Analysis and Weighted Gene Co-expression Network Analysis. We provide a signature of key cancer-heterogeneity genes highly associated with the intratumor spatial gradient and show that it is enriched in genes with correlation between methylation and expression levels.

ORGANISM(S): Homo sapiens

SUBMITTER: Amandine Etcheverry

PROVIDER: E-MTAB-5109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity.

Aubry Marc M de Tayrac Marie M Etcheverry Amandine A Clavreul Anne A Saikali Stéphan S Menei Philippe P Mosser Jean J

Oncotarget 20150501 14

Glioblastoma (GB) is a highly invasive primary brain tumor that almost systematically recurs despite aggressive therapies. One of the most challenging problems in therapy of GB is its extremely complex and heterogeneous molecular biology. To explore this heterogeneity, we performed a genome-wide integrative screening of three molecular levels: genome, transcriptome, and methylome. We analyzed tumor biopsies obtained by neuro-navigation in four distinct areas for 10 GB patients (necrotic zone, tu ...[more]

PMID: 25940437

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