4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies

ABSTRACT: Molecular profiling of effect of TNFα neutralization in contrast to anti-IL-17A or anti-IL-17F treatment for 28 days in lungs of M. tuberculosis infected C57BL/6 mice. Animals were treated once per week (starting day-1) with anti-mouse IL-17A or IL-17F antibodies (20 mg/kg i.p.), anti-mouse TNFα antibody (10 mg/kg), respective isotype control antibodies. Moreover, infected and non-infected TNFα-deficient mice were also analysed. Gene expression data revealed major changes of inflammatory and immune gene expression signatures 4 weeks post-infection (including host-pathogen interactions, macrophage recruitment, activation and polarization, host-anti-mycobacterial activities, immunomodulatory responses and extracellular matrix metallopeptidases) after TNFα blockade, while IL-17A or IL-17F

ORGANISM(S): Mus musculus

SUBMITTER: Elaine Tritto 

PROVIDER: E-MTAB-5218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress