Coronary artery disease-associated genotype data in Mediterranean populations

ABSTRACT: We wanted to explore the genomic regions 1p13, 1q41, 9p21 and 10q11, which are among the labeled “top 12 golden loci” linked to coronary artery disease (CAD) risk, in order to see whether their geographic variation could be explained by demographic effects. To do this, we have genotyped these risk regions in a set of Mediterranean populations. Genomic DNA was extracted from blood cells using a Blood Midi kit (Omega Biotek, USA) according to manufacturer's procedures. DNA samples were genotyped for a combined set of 366 SNPs using an Illumina Custom GoldenGate Panel. SNPs were selected as a representative set of the common variation in the four genomic regions, according to the following criteria: i) average coverage of 1 SNP every 1.5 kb, ii) minor allele frequency (MAF) higher than 0.

ORGANISM(S): Homo sapiens

SUBMITTER: Miguel Alvarez 

PROVIDER: E-MTAB-5265 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress