COPD progression in C57l/6 mice in response to chronic exposure (up to 7 months) to conventional cigarette smoke or a prototype modified risk tobacco product (pMRTP) and the impact of cessation or switching to pMRTP after initial exposure to conventional cigarette smoke

ABSTRACT: Smoking of combustible cigarettes has a major impact on human health, so the tobacco industry is developing modified risk tobacco products (MRTP) to reduce this health risk. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the potential of such a prototype (pMRTP) to reduce health risk. We investigated physiological endpoints in parallel with transcriptomics, lipidomics, and proteomics profiles in mice exposed to conventional cigarette smoke (3R4F) or a pMRTP aerosol for up to 7 months. We also included a cessation group and a switching-to-pMRTP group (after 2 months of 3R4F exposure) in addition to the control (fresh air-exposed) group, to understand the potential risk reduction of switching to pMRTP compared with continuo

ORGANISM(S): Mus musculus

SUBMITTER: Vincenzo Belcastro 

PROVIDER: E-MTAB-5281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress