Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HumanMethylation450 data from the pilot study of the 'Personal Genome Project UK': PGP-UK10 and the first three genome donations

ABSTRACT: This study consists of 24 genome-wide methylation profiles which have been generated from blood and saliva samples collected from ten volunteers in the Personal Genome Project UK. The Personal Genome Project UK aims to create publicly available genome, health and trait data, and these ten volunteers represent the pilot study (PGP-UK10) and the first three genome donation participants. These samples were bisulphite converted using the EZ DNA methylation kit (Zymo), using the alternative incubation conditions recommended for HumanMethylation450 BeadChip (Illumina). Genome-wide DNA methylation was then profiled using the HumanMethylation450 BeadChip (Illumina).

ORGANISM(S): Homo sapiens

SUBMITTER: Amy Webster

PROVIDER: E-MTAB-5377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

RNA-seq data from the pilot study of the 'Personal Genome Project UK': PGP-UK10

Project description:This study consists of 10 whole genome RNA-seq profiles which have been generated from blood samples collected from ten different volunteers in the Personal Genome Project UK

2018-03-04 | E-MTAB-6523 | biostudies-arrayexpress

HipSci Illumina 450K Methylation analysis _open access data for healthy volunteers

Project description:The Human Induced Pluripotent Stem Cells Initiative (HipSci) project brings together diverse constituents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies. In this sub-study we performed Methylation analysis using the Infinium HumanMethylation450 BeadChip on iPS cells generated from skin biopsies from healthy volunteers.

2015-11-16 | E-MTAB-4059 | biostudies-arrayexpress

Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk

Project description:Genome wide DNA methylation profiling of normal colon samples. The Illumina Infinium HumanMethylation450 and EPIC Beadchip arrays were used to obtain DNA methylation profiles across approximately 450,000 and 850,000 CpGs. Samples were from nomal colons of 334 subjects with low, medium or high CRC risk according to their personal adenoma or cancer history.

2019-12-31 | GSE132804 | GEO

HumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs

Project description:This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influence of genetic heterogeneity which often affects case-control epigenome-wide association studies of common diseases. Twins were recruited from two cohorts; Arthritis Research UK in Manchester and TwinsUK in London.

2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress

Illumina Infinium HumanMethylation450 Genome-wide Methylation Levels at Baseline and 6 months after undergoing Aerobic and Stretch Exercise Activities

Project description:Elderly AA volunteers confirmed MCI assigned into a six-month program of aerobic exercise (eleven participants) underwent a 40-minute supervised-training 3-times/week and controls (eight participants) performed stretch training. Participants had maximal oxygen consumption (VO2max) test and Genome-wide methylation levels at CpG sites using the Infinium HumanMethylation450 BeadChip assay at baseline and after a six-month exercise program.

2022-12-31 | E-MTAB-11166 | biostudies-arrayexpress

Analysis of epigenetic changes in F-36P leukemic cells by arsenic disulfide treatment

Project description:Genome wide DNA methylation profiling of F-36P leukemic cells treated by arsenic disulfide, The Illumina HumanMethylation450 BeadChip was used to obtain DNA methylation profiles Bisulphite converted DNA from the 3 samples were hybridised to the Illumina HumanMethylation450 BeadChip

2016-08-01 | E-GEOD-51196 | biostudies-arrayexpress

Array-based determination of DNA methylation in children born small for gestational age

Project description:Genome wide DNA methylation profiling of peripheral blood samples obtained from normal controls and children born SGA. Illumina's HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 450.000 CpGs. Bisulphite converted DNA from the 110 samples were hybridised to the Illumina HumanMethylation450 Beadchip.

2016-07-03 | E-GEOD-47880 | biostudies-arrayexpress

Predicting genome-wide DNA methylation

Project description:Genome wide DNA methylation profiling of normal whole blood samples. The data consist of 100 samples with Illumina HumanMethylation450 BeadChip data. Bisulphite converted DNA from the 100 samples were hybridized to the Illumina HumanMethylation450 BeadChip

2014-11-05 | E-GEOD-62992 | biostudies-arrayexpress

Differential DNA methylation in Rheumatoid arthritis

Project description:Genome-wide DNA methylation level was studied to determine whether Rheumatoid arthritis patients (cases) has methylation differences comparing to normal controls in PBLs. We used Illumina HumanMethylation450 BeadChip array to determine the genome-wide DNA methylation difference in PBLs from Rheumatoid arthritis patients (cases) and normal controls Bisulphite converted DNA from the Rheumatoid arthritis patients (cases) and normal controls were hybridized to the Illumina Illumina HumanMethylation450 BeadChip arrays

2013-01-21 | E-GEOD-42861 | biostudies-arrayexpress

Methylome study in Nasopharyngeal Carcinoma (NPC)

Project description:Aberrant methylation at the promoter region of tumor suppressors is frequently reported in NPC; however, genome-wide methylation changes have not been comprehensively investigated. Therefore, we systematically analyzed methylome data in 25 primary NPC tumors and non-tumor counterparts using Illumina HumanMethylation450 BeadChip. Bisulphite converted DNA from 50 samples were hybridized to the Illumina HumanMethylation450 BeadChip. Bisulphite pyrosequencing was used as an independent method to validate the BeadChip results.

2016-07-03 | E-GEOD-62336 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data