Dataset Information
Transcription profile of induced transgenic AhCreICDE/wt and AhCreEYFP/wt mice small intestine
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Joanna Fowler
PROVIDER: E-MTAB-543 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance.
PloS one 20110616 6
Here we investigate the effects of expressing an activated mutant of Notch (ICD-E) in an inducible transgenic mouse model. Hepatic expression of ICD-E in adult animals has no detectable phenotype, but simultaneous induction of ICD-E in both the liver and small intestine results in hepatic steatosis, lipogranuloma formation and mild insulin resistance within 96 hours. This supports work that suggests that fatty liver disease may result from disruption of the gut-liver axis. In the intestine, ICD- ...[more]
