Deletion of ribosomal protein genes is a common vulnerability in human cancer, particularly in concert with TP53 mutation

ABSTRACT: Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. As a part of a large-scale study aimed at identifying associations between RPG deletions, p53 activation, and perturbations of rRNA maturation patterns, we analyzed a series of blood and bone marrow samples from children with acute lymphoblastic leukemia (ALL), as a baseline genomic characterization.

ORGANISM(S): Homo sapiens

SUBMITTER: Björn Nilsson 

PROVIDER: E-MTAB-5450 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress