Gene expression in cutaneous lupus erythematosus

ABSTRACT: Lesional skin biopsies were taken from patients with active, untreated lupus skin disease (chronic discoid lupus erythematosus, CDLE, n=6; subacute cutaneous lupus erythematosus, SCLE, n=5). Healthy control specimens (HC) were obtained from healthy skin of 5 patients undergoing plastic surgery. In every case, two 4mm punch biopsies were taken. One was flash-frozen in liquid nitrogen and afterwards processed for mRNA isolation. The second biopsy was fixed in 5% formalin solution overnight, and was proceeded for histological investigation.The one-color Agilent 60-mer oligo microarray (Agilent, Santa Clara, CA) was used for gene expression analyses. Statistical analyses were performed using the Agilent Feature Extraction Software™ and the Rosetta Resolver™ gene expression data analysis s

ORGANISM(S): Homo sapiens

SUBMITTER: Joerg Wenzel 

PROVIDER: E-MTAB-5542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress