Atorvastatin Reduces β-Adrenergic Dysfunction in Rats with Diabetic Cardiomyopathy

ABSTRACT: Background: In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and mortality in diabetic patients which are attributed to “pleiotropic” effects. The objective of our study was to investigate the role of statin treatment on β-adrenergic dysfunction in diabetic rat cardiomyocytes. Methods: β-adrenergic responses were investigated in vivo (echocardiography) and ex vivo (left ventricular papillary muscles) in healthy and streptozotocin-induced diabetic rats, who were pre-treated or not by oral atorvastatin over 15 days (50 mg.kg-1.day-1). Micro-array analysis and

ORGANISM(S): Rattus norvegicus

SUBMITTER: Nicolas Cagnard 

PROVIDER: E-MTAB-5594 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress