Cytokine-mediated natural killer cells effects impair hematopoietic stem cell function

ABSTRACT: We demonstrated that NK cell activity affects HSCs frequency in vitro as well as hematopoietic reconstitution in vivo. Gene expression and cytokine profile assays revealed the potential players of this HSC-NK cell regulation, such as IFNγ. Besides the known role of C/EBPg in NK cell differentiation, we demonstrated that it is also essential for NK-cytokine mediated HSC regulation. Finally, NK cell depletion from murine and human bone marrow favored transplant chimerism.

ORGANISM(S): Mus musculus

SUBMITTER: Meritxel Alberich-Jorda 

PROVIDER: E-MTAB-5604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress