COMPARATIVE SYSTEMS TOXICOLOGY ANALYSIS OF CIGARETTE SMOKE AND AEROSOL FROM A CANDIDATE MODIFIED RISK TOBACCO PRODUCT IN ORGANOTYPIC HUMAN GINGIVAL EPITHELIAL CULTURES: A 3-DAY REPEATED EXPOSURE STUDY.

ABSTRACT: Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. Using a systems toxicology approach, we investigated and compared the exposure effects of a reference cigarette (3R4F) and a heat-not-burn technology-based candidate MRTP, the Tobacco Heating System (THS) 2.2. Human gingival epithelial organotypic cultures were repeatedly exposed (3 days) for 28 min at two matching concentrations of cigarette smoke (CS) or THS2.2 aerosol. Results showed only minor histopathological alterations and minimal cytotoxicity upon THS2.2 aerosol exposure compared to CS (1% for THS2.2 aerosol vs. 30% for CS, at the high concentration). Among the 14 pr

ORGANISM(S): Homo sapiens

SUBMITTER: Filippo Zanetti 

PROVIDER: E-MTAB-5608 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress